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L-Triiodothyronine, also known as T3, is a thyroid hormone. It
affects almost every physiological process in the body, including
growth and development, metabolism, body temperature, and heart
Production of T3 and its prohormone thyroxine (T4) is activated by
thyroid-stimulating hormone (TSH), which is released from the
pituitary gland. This pathway is regulated via a closed-loop
feedback process: Elevated concentrations of T3, and T4 in the
blood plasma inhibit the production of TSH in the pituitary gland.
As concentrations of these hormones decrease, the pituitary gland
increases production of TSH, and by these processes, a feedback
control system is set up to regulate the amount of thyroid hormones
that are in the bloodstream.
As the true hormone, the effects of T3 on target tissues are
roughly four times more potent than those of T4. Of the thyroid
hormone that is produced, just about 20% is T3, whereas 80% is
produced as T4. Roughly 85% of the circulating T3 is later formed
in the thyroid by removal of the iodine atom from the carbon atom
number five of the outer ring of T4. In any case, the concentration
of T3 in the human blood plasma is about one-fortieth that of T4.
This is observed in fact because of the short half-life of T3,
which is only 2.5 days. This compares with the half-life of T4,
which is about 6.5 days.
It affects almost every physiological process in the body,
including growth and development, metabolism, body temperature, and
heart rate. T3 increases the basal metabolic rate and, thus,
increases the body's oxygen and energy consumption. The basal
metabolic rate is the minimal caloric requirement needed to sustain
life in a resting individual. T3 acts on the majority of tissues
within the body, with a few exceptions including the spleen and
testis. It increases the production of the Na+/K+ -ATPase and, in
general, increases the turnover of different endogenous
macromolecules by increasing their synthesis and degradation.